Peer-reviewed Publications

PEER-REVIEWED PUBLICATIONS (Last three years) - click on links for full publications

[NRI staff and SVHAS staff in BOLD]


Rogers JM, Duckwork J, Middleton S, Steenbergen V, Wilson PH. Elements virtual rehabilitation improves motor, cognitive, and functional outcomes in adult stroke: evidence from a randomized controlled pilt study. Journal of NeuroEngineering and Rehabilition 2019; 16:56.doi: 10.1186/s12984-019-0531-y

Middleton S, Dale S, Cheung W, Cadilhac D, Grimshaw J, Levi C, McInnes E, Considine J, McElduff P, Gerraty R, Craig L, Schadewaldt V, Fitzgerald M, Quinn C, Cadigan G, Denisenko S, Longworth M, Ward J, D’Este C.  Nurse-initiated acute stroke care in Emergency Departments: Results from the T3 implementation cluster randomised controlled trial.  Stroke 2019. Published online.  Accepted 14 March 2019. DOI: 10.1161/STROKEAHA.118.020701

Cadilhac DA, Grimley R, Kilkenny MF, Andrew NE, Lannin NA, Hill K, Grabsch B, Levi CR, Thrift AG, Faux SG, Wakefield J, Cadigan G, Donnan GA, Middleton S, and Anderson CS. Multicenter, prospective, controlled, before-and-afer, quality improvement study (Stroke 123) of acute stroke care. Stroke 2019. Published online 21 May 2019.

Martinez-Garduno CM, Rodgers J, Phillips R, Gunaratne AW, Drury P, McInnes E. The Surgical Patients' Pressure Injury Incidence (SPPII) study: a cohort study of surgical patients and processes of care. Wound Practice and Research (Accepted April 2019)

Tavender E, Babl FE, Middleton S. A primer for clinical researchers in the emergency department: Part 8. Implementation Science: An introduction. Emergency Medicine Australasia (EMA) Journal 2019. In Press. Accepted 21 March 2019.

Minhas J, Wang X, Lavados P, Moullaali T, Arima H, Billot L, Hackett M, Olavarría V, Middleton S, Pontes-Neto O, de Silva A, Lee T, Pandian J, Mead G, Watkins C, Chalmers J, Anderson C, Robinson T. Head Positioning and Blood Pressure Variability in Acute Stroke: A Post-Hoc Analysis of the HeadPoST Study. Journal of Human Hypertension.

Schadewaldt V, McElduff B, D’Este C, McInnes E, Dale S, Gunaratne A, Squires J, Cadilhac DA, Middleton S. Validating the Alberta Context Tool in a multi-site Australian Emergency Department nurse population. Plos One 2019; 14(4): e0215153.

Craig LE, Middleton S, Hamilton H, Cudlip F, Swatzell V, Alexandrov AV, Lightbody E, Watkins C, Philip S, Cadilhac DA, McInnes E, Dale S, Alexandrov AW. Does the Addition of Non-Approved Inclusion and Exclusion Criteria for rtPA Impact Treatment Rates? Findings in Australia, the UK, and the USA. Interventional Neurology 2019;8(1):1–12.

Cadilhac D, Kilkenny M, Lannin N, Dewey H, Levi C, Hill K, Grabsch B, Grimley R, Blacker D, Thrift A, Middleton S, Anderson C, Donnan G. Outcomes for patients with in-hospital stroke: a multicentre study from the Australian Stroke Clinical Registry. Journal of Stroke and Cerebrovascular Diseases 2019; 28(5): 1302-1310.

Middleton S, McElduff P, Drury P, D’Este C, Cadilhac DA, Dale S, Grimshaw J, Ward J, Quinn C, Cheung NW, Levi C. Vital sign monitoring following stroke associated with 90-day independence: a secondary analysis of the QASC cluster randomized trial. International Journal of Nursing Studies 2019; 89: 72-79. In Press. [Epub ahead of print]

Kilkenny M, Kim J, Andrew N, Sundararajan V, Thrift AG, Katzenellenbogen JM, Flack F, Gattellari M, Boyd JH, Anderson P, Lannin N, Sipthorp M, Chen Y, Johnston T, Anderson CS, Middleton S, Donnan GA, Cadilhac DA. Maximising data value and avoiding data waste: a validation study in stroke research. Medical Journal of Australia 2019; 210 (1): 27-31. doi: 10.5694/mja2.12029

Andrew N, Middleton S, Grimley R, Anderson C, Donnan G, Lannin N, Salama E, Grabsch B, Kilkenny M, Squires J, Cadilhac D. Hospital organizational context and delivery of evidence-based stroke care: a cross-sectional study. Implementation Science 2019; 14(6).   



McInnes E, Jammali-Blasi A, Bell-Syer SE, Leung V. Support surfaces for pressure ulcer treatment. Cochrane Database of Systematic Reviews 2018; Issue 10. Art. No.: CD009490.doi: 10.1002/14651858.CD009490.pub2

Godecke E, Rai T, Cadilhac DA, Armstrong E, Middleton S, Ciccone N, Whitworth A, Rose ML, Holland A, Ellery F, Hankey GJ, Bernhardt J for the VERSE Collaboration. Statistical analysis plan (SAP) for the Very Early Rehabilitation in Speech (VERSE) after stroke trial: an international 3-arm clinical trial to determine the effectiveness of early, intensive, prescribed, direct aphasia therapy. International Journal of Stroke 2018; 13(8): 863-880.

Lynch E, Ramanathan S, Middleton S, Bernhard J, Nilsson M, Cadilhac DA. A mixed methods study to explore opinions of research translation held by researchers working in a Centre of Research Excellence in Australia. BMJ Open 2018; 8:e022357. [Online publication] doi: 10.1136/bmjopen-2018-022357

Kilkenny M, Lannin N, Levi C, Faux S, Dewey H, Grimley R, Hill K, Grabsch B, Kim J, Hand P, Crosby V, Gardner M, Rois-Gnecco J, Thijs VN, Anderson CS, Donnan G, Middleton S, Cadilhac DA on behalf of the AuSCR Consortium. Weekend hospital discharge is associated with suboptimal care and outcomes: An observational Australian Stroke Clinical Registry study. International Journal of Stroke 2018. 0(0)1–9. [Epub ahead of print] doi: 10.1177/1747493018806165

Malone V, Ezard N, McInnes E, Clifford B, Bonevski B, Middleton S. A systems change intervention for nurse-led smoking cessation care in hospitals.  Collegian 2018; 26(2): 235-241. doi: 10.1016/j.colegn.2018.07.007

Ramanathan S, Reeves P, Deeming S, Berrnhardt J, Nilsson M, Cadilhac DA, Walker R, Carey L, Middleton S, Lynch E, Searles A. Implementing a protocol for a research impact assessment of the Centre for Research Excellence in Stroke Rehabilitation and Brain Recovery. Health Research Policy and Systems 2018; 16(71). In Press.  [Epub ahead of print] doi: 10.1186/s12961-018-0349-2

Rogers JM, Bechara J, Middleton S, Johnstone SJ. Acute EEG patterns associated with transient ischemic attack. Clinical EEG & Neuroscience 2018; 50(3): 196-2014.doi: 10.1177/1550059418790708

Busingye D, Kilkenny MF, Purvis T, Kim J, Middleton S, Campbell BCV, Cadilhac DA. Is length of time in a stroke unit associated with better outcomes for patients with stroke in Australia? An observational study. BMJ Open 2018; 8(11):e022536. [Online publication] doi: 10.1136/bmjopen-2018-022536

Morgan P, Coleman P, Martinez-Garduno C, Gunaratne A, McInnes E, Middleton S. Implementation of a patient blood management program in an Australian private hospital Orthopaedic Unit. Journal of Blood Medicine 2018; 9: 83-90. doi: 10.2147/jbm.s157571

Muller C, Cheung WA, Dewey H, Churilov L, Middleton S, Thijs V, Ekinci E, Levi C, Lindley R, Donnan GA, Parsons M, Bladin C. Treatment with Exenatide in Acute Ischaemic Stroke (TEXAIS) trial Protocol: a prospective, randomised, open label, blinded end-point study of Exenatide vs. Standard Care in Post Stroke Hyperglycaemia. International Journal of Stroke 2018; 13(8): 857–862.

Alexandrov AW, Palazzo P, Biby S, Doerr A, Dusenbury W, Young R, Lindstrom A, Grove M, Tsivgoulis G, Middleton S, Alexandrov AV. Back to basics: Adherence with guidelines for glucose and temperature control in an American comprehensive stroke center sample. Journal of Neuroscience Nursing 2018; 50(3): 131-137. doi: 10.1097/JNN.0000000000000358

Aminov A, Rogers J, Middleton S, Caeyenberghs K, Wilson PH. What do randomized controlled trials say about virtual rehabilitation in stroke? A systematic literature review and meta-analysis of upper-limb and cognitive outcomes.  Journal of NeuroEngineering and Rehabilitation 2018; 15:29. doi: 10.1186/s12984-018-0370-2

Haines MM, Brown B, D’Este CA, Yano EM, Craig JC, Middleton S, Castaldi PA, Pollock CA, Needham K, Watt WH, Elliott EJ, Scott A, Dominello A, Klineberg E, Atkinson J, Paul C, Redman S, on behalf of the Clinical Networks Research Group. Improving the quality of healthcare: a cross-sectional study of the features of successful clinical networks. Public Health Research Practice 2018; 28 (4) e28011803.

Kilkenny MF, Lannin NA, Anderson CS, Dewey H, Kim J, Barclay-Moss K, Levi C, Faux S, Hill K, Grabsch B, Middleton S, Thrift A, Grimley R, Donnan G, Cadilhac D. Quality of life is poorer for patients with stroke who require an interpreter: An observational Australian Registry study. Stroke 2018; 49(3): 761-764. doi: 10.1161/STROKEAHA.117.019771

Cadilhac DA, Andrew NE, Kilkenny MF, Hill K, Grabsch B, Lannin NA, Thrift A, Anderson CS, Donnan GA, Middleton S, Grimley R. Improving quality and outcomes of stroke care in hospitals: protocol and statistical analysis plan for the Stroke123 implementation study. International Journal of Stroke 2018; 13(1): 96-106. doi: 10.1177/1747493017730741

Andrew NE, Kim J, Thrift AG, Kilkenny MF, Lannin NA, Anderson CS, Donnan GA, Hill K, Middleton S, Levi C, Faux S, Grimley R, Gange N, Geraghty R, Ermel S, Cadilhac DA.  Prescription of antihypertensive medication at discharge influences survival following stroke. Neurology 2018; 90(9): e745-e753. doi: 10.1212/WNL.0000000000005023

Gardner G, Gardner A, Middleton S, Considine J, Fitzgerald G, Christofis L, Doubrovsky A, Adams M, O’Connell J. Mapping workforce configuration and operational models in Australian Emergency Departments: A national survey. Australian Health Review 2018; 42: 340-347. doi: 10.1071/AH16231



Lannin NA, Anderson CS, Kim J, Kilkenny M, Bernhardt J, Levi C, Dewey H, Bladin C, Hand P, Castley J, Hill K, Faux S, Grimley R, Grabsch B, Middleton S, Donnan G, Cadilhac D. Treatment and outcomes of working aged adults with stroke: results from a national prospective registry. Neuroepidemiology 2017; 49(3-4): 113-120. doi: 10.1159/000484141

Kawano H, Bivard A, Parsons M, Paul C, Krause M, D’Este C, Bladin C, Lindley R, Attia J, Henskens F, Longworth M, Middleton S, Ryan A, Kerr E, Sanson-Fisher R, Levi C. Hospital arrival times and post-imaging delays in stroke thrombolysis implementation. International Journal of Neurological Disorders & Stroke 2017; 5(3): 1127-1132.

Aminov A, Rogers JM, Wilson PH, Johnstone SJ, Middleton S. Acute single channel EEG predictors of cognitive function after stroke. PLOS ONE 2017; 12(10): e0185841.

Purvis T, Kilkenny MF, Middleton S, Cadilhac DA. Influence of stroke coordinators on delivery of acute stroke care and hospital outcomes: An observational study. International Journal of Stroke 2017; 13 (6): 585-591. doi: 10.1177/1747493017741382

Middleton S, Bruch D, Martinez-Garduno C, Dale S, McNamara M. International uptake of a proven intervention to reduce death and dependency in acute stroke: A cross-sectional-survey following the QASC Trial. Worldviews on Evidence-Based Nursing 2017; 14(6):447-454. Published online 14 August 2017. doi: 10.1111/wvn.12253

Billot L, Woodward M, Arima H, Hackett M, Munoz Venturelli P, Lavados P, Brunser A, Peng B, Cui L, Song L, Heritier S, Jan S, Middleton S, Olavarría V, Lim J, Robinson T, Anderson CS. Statistical analysis plan for the Head Position in Stroke Trial (HeadPoST): an international cluster cross-over randomised trial. International Journal of Stroke 2017; 12(6): 667-670. doi: 10.1177/1747493017701943

Ferguson C, Inglis SC, Newton PJ, Middleton S, Macdonald PS, Davidson PM. Barriers and enablers to adherence to anticoagulation in heart failure with atrial fibrillation: patient and provider perspectives. Journal of Clinical Nursing 2017; 26(23-24): 4325-4334. doi: 10.1111/jocn.13759

Luker JA, Bernhardt J, Graham ID, Middleton S, Lynch EA, Thayabaranathan T, Craig L, Cadilhac DA. Interventions for the uptake of evidence-based recommendations in acute stroke settings (Protocol). Cochrane Database of Systematic Reviews 2017; Issue 1. Art. No.: CD012520. doi: 10.1002/14651858.CD012520

Westbrook JI, Li L, Hooper TD, Raban MZ, Middleton S, Lehnbom EC. Effectiveness of a ‘Do not interrupt’ bundled intervention to reduce interruptions during medication administration: A cluster randomised controlled feasibility study. BMJ Quality & Safety 2017; 26: 734-742. doi: 10.1136/bmjqs-2016-006123

Cadilhac D, Andrew NE, Salama ES, Hill K, Middleton S, Horton E, Meade I, Kuhle S, Nelson MR, Grimley R, Australian Stroke Clinical Registry Consortium. Improving discharge care: the potential of a new organisational intervention to improve discharge after hospitalisation for acute stroke, a controlled before-after pilot study. BMJ Open 2017; 7(8): e016010. doi: 10.1136/bmjopen-2017-016010

Mikulik R, Ylikotila P, Roine R, Brozman M, Middleton S. Leaving a legacy of Stroke in Europe: A community of dedicated professionals is changing the face of stroke in Europe. Oruen – The CNS Journal 2017; 3(1): 8-18.

Craig L, Taylor B, Grimley R, Cadilhac D, McInnes E, Phillips R, Dale S, O’Connor D, Levi C, Fitzgerald M, Considine J, Grimshaw J, D’Este C, Gerraty R, Cheung W, Ward J, Middleton S. Development of a theory-informed implementation intervention to improve the triage, treatment and transfer of stroke patients in emergency departments using the Theoretical Domains Framework (TDF): The T3 Trial. Implementation Science 2017; 12: 88. doi: 10.1186/s13012-017-0616-6

Anderson CS, Arima H, Lavados P, Billot L, Hackett ML, Olavarria VV, Munoz-Venturelli P, Brunser A, Peng B, Cui L, Song L, Rogers K, Middleton S, Lim JY, Forshaw D, Lighbody CE, Woodward M, Pontes-Neto O, de Silva A, Lin RT, Lee TH, Pandian JD, Mead GE, Robinson T, Watkins C for the HeadPoST Investigators and Coordinators. Cluster crossover trial of head positioning in acute stroke. New England Journal of Medicine 2017; 376: 2437-2447. doi: 10.1056/NEJMoa1615715

Cadilhac D, Kilkenny M, Levi C, Lannin N, Thrift A, Kim J, Grabsch B, Churilov L, Dewey H, Hill K, Faux S, Grimley R, Castley H, Hand P, Wong A, Herkes G, Gill M, Crompton D, Middleton S, Donnan G, Anderson C. Risk-adjusted mortality rates following stroke by hospital: evidence from the Australian Stroke Clinical Registry (AuSCR). Medical Journal of Australia 2017; 206(8): 345-350. doi: 10.5694/mja16.00525

Ferguson C, Inglis S, Newton P, Middleton S, Macdonald P, Davidson P. Multi-morbidity, frailty and self-care: important considerations in treatment with anticoagulation drugs. Outcomes of the AFASTER study. European Journal of Cardiovascular Nursing 2017; 16(2), 113-124. doi: 10.1177/1474515116642604

Craig L, Churilov L, Olenko L, Cadilhac D, Grimley R, Dale S, Martinez-Garduno C, McInnes E, Considine J, Grimshaw JM, Middleton S. Testing a systematic approach to identify and prioritise barriers to successful implementation of a complex healthcare. BMC Medical Research Methodology 2017; 17: 24 Epub 7 February 2017. doi: 10.1186/s12874-017-0298-4

Middleton S, Coughlan K, Mnatzaganian G, Choy N, Dale S, Jammali-Blasi A, Levi C, Grimshaw J, Ward J, Cadilhac D, McElduff P, Hiller J, D’Este C. Mortality reduction for fever, hyperglycaemia and swallowing nurse-initiated stroke intervention: QASC trial follow-up. Stroke 2017; 48: 1331-1336. doi: 10.1161/STROKEAHA.116.016038

Cadilhac D, Andrew N, Lannin N, Middleton S, Levi C, Dewey H, Grabsch B, Faux S, Hill K, Grimley R, Wong A, Sabet A, Butler E, Bladin C, Bates T, Groot P, Castley H, Donnan G, Anderson C. Quality of acute care and long-term quality of life and survival: the Australian Stroke Clinical Registry. Stroke 2017; 48(4): 1026-1032. doi: 10.1161/STROKEAHA.116.015714

Dennis S, Reddel H, Middleton S, Hasan I, Hermiz O, Phillips R, Crockett A, Vagholkar S, Marks G, Zwar N. Barriers and outcomes of an evidence-based approach to diagnosis and management of chronic obstructive pulmonary disease (COPD) in Australia: A qualitative study. Family Practice 2017; 34(4): 485-490. doi: 10.1093/fampra/cmw103

Whitty JA, McInnes E, Bucknall T, Webster J, Gillespie BM, Banks M, Thalib L, Wallis M, Cumsille J, Roberts S, Chaboyer W. The cost-effectiveness of a patient centered pressure ulcer prevention care bund: Findings from the INTACT cluster randomised trial. International Journal of Nursing 2017; 75: 35 – 42. doi: 10.1016/j.ijnurstu.2017.06.014

Helms C, Gardner A, McInnes E. The use of advanced web-based survey design in Delphi research. Journal of Advanced Nursing 2017; 73:3168–3177. doi: 10.1111/jan.13381

Chaboyer W, Harbeck E, Bucknall T, McInnes E, Thalib, L, Whitty, J, Wallis M., Gillespie B.  Initial psychometric testing and validation of the Patient Participation in Pressure Injury Prevention scale. Journal of Advanced Nursing 2017; 73(9): 2237 – 2247. doi: 10.1111/jan.13289

Roberts S, McInnes E, Bucknall T, Wallis, M, Banks M, Chaboyer W.  Process evaluation of a cluster randomised trial testing a pressure ulcer prevention care bundle: a mixed methods study. Implementation Science 2017; 12: 18. doi: 10.1186/s13012-017-0547-2

Roberts S, Wallis M, McInnes E, Bucknall T, Banks M, Ball L, Chaboyer W. Patients’ perceptions of a pressure ulcer prevention care bundle in hospital: a qualitative descriptive study to guide evidence-based practice. Worldviews on Evidence-Based Nursing 2017 14(5): 385-393. doi: 10.1111/wvn.12226

Webster J, Bucknall T, Wallis M, McInnes E, Roberts S, Chaboyer W. Does participating in a clinical trial affect subsequent nursing management? Post-trial care for participants recruited to the INTACT pressure ulcer prevention trial. International Journal of Nursing Studies 2017; 71: 34-38.  doi: 10.1016/j.ijnurstu.2017.02.022

Chaboyer W, Bucknall T, Gillespie B, Thalib L, McInnes E, Considine J, Murray E, Duffy P, Tuck M, Harbeck E. Adherence to evidence-based pressure injury prevention guidelines in routine clinical practice: a longitudinal study. International Wound Journal 2017; 14(6): 1290-1298. doi: 10.1111/iwj.12798

Boaden E, Doran D, Burnell J, Clegg A, Dey P, Hurley M, Alexandrov A, McInnes E, Watkins CL. Screening for aspiration risk associated with dysphagia in acute stroke: Protocol. Cochrane Database of Systematic Reviews 2017; (6) CD012679. doi: 10.1002/14651858.CD012679